I-Quercetin Encibilikayo Emanzini Yokulethwa Kwezakhi Eziphezulu Okufakiwe Isithombe

I-Quercetin Encibilika Ngamanzi Yokulethwa Kwezakhi Eziphezulu

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Inzuzo:Okungeyona i-GMO,I-Non-Allergen,Isisekelo sokuzitshala samakhambi,I-workshop evamile ye-GMP, isevisi eyenziwe ngokwezifiso iyatholakala

Ukucaciswa: I-10% i-quercetin powder encibilikayo

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I-Quercetin Encibilika Ngamanzi: Ukuthuthukisa I-Bioavailability kanye Nokuphayona Inkathi Entsha Yezempilo

I-Quercetin, isakhi se-flavonoid esitholakala kakhulu ekudleni okusekelwe ezitshalweni okuhlukahlukene okufana no-anyanisi, ama-apula, namajikijolo, sekuyisikhathi eside iyinhloko ocwaningweni lwesayensi nezingxoxo zezempilo, ngenxa ye-antioxidant enamandla, eqeda ukuvuvukala, kanye neminye imisebenzi yebhayoloji ehlukahlukene. Kodwa-ke, ukuncibilika kwawo okungekuhle ngokwemvelo emanzini kuthikameza kakhulu ukumuncwa kwawo kanye nokusetshenziswa kwawo emzimbeni womuntu, ngaleyo ndlela kunciphisa ukugcwaliseka okuphelele kwezinzuzo zawo zezempilo. Eminyakeni yamuva nje, ngentuthuko eqhubekayo kwezesayensi nobuchwepheshe, kuye kwavela i-quercetin encibilika emanzini, inqoba izinselele zokuncibilika kwe-quercetin yendabuko futhi yethula i-spectrum ebanzi yezinhlelo zokusebenza kanye nezinzuzo eziyingqayizivele.

I-Revolutionizing Bioavailability: Ukunqoba Izithiyo Zokumunca

I-quercetin yendabuko, ngenxa yokuncibilika kwayo okuphansi kwamanzi, idonsa kanzima ukuncibilika emgudwini wamathumbu ngemva kokuphathwa ngomlomo, okuholela esilinganisweni esiphansi kakhulu sokumuncwa. Ucwaningo lubonisa ukuthi izinga lokumunca emathunjini licishe libe ngu-2%. Ngokuphambene, i-quercetin encibilikayo emanzini isebenzisa ubuchwepheshe obuphambili, obufana nobuchwepheshe be-nanomiclle kanye nobuchwepheshe bokufakwa kwe-cyclodextrin, ukuze ithuthukise ngokuphawulekayo ukunyibilika kwayo emanzini. Isibonelo, i-Dryland New Materials Laboratory ye-South Subtropical Crops Research Institute, i-Chinese Academy of Tropical Agricultural Sciences, ilungise ngempumelelo ama-nanomicelles alayishwe i-quercetin ngokusebenzisa izindlela zokuhlanganisa amakhemikhali. Lokhu okusha kuthuthukise kakhulu ukuncibilika kwamanzi e-quercetin, ukubukeka kwesithombe, kanye nokusebenza kahle kwamaselula. Ngenxa yalokhu, i-quercetin ingancibilika kahle oketshezini lwamathumbu, ikhulise indawo yokuxhumana namaseli e-mucosal wamathumbu futhi ikhulise kakhulu ukumuncwa kwayo emzimbeni womuntu. Ucwaningo olufanelekile lubonisa ukuthi i-bioavailability ye-quercetin encibilika emanzini inganyuswa izikhathi ezimbalwa noma ngisho nangaphezulu uma iqhathaniswa ne-quercetin evamile, okwenza umzimba ukwazi ukumunca kangcono futhi usebenzise izingxenye ezisebenzayo ze-quercetin futhi uvule ngokugcwele imiphumela yayo ekhuthaza impilo.

Izicelo Zezempilo Ezihlukahlukene

1. I-Blood Glucose Regulation
I-quercetin encibilika emanzini inikeza ithemba elisha kubantu abakhathazekile ngempilo yeglucose yegazi. Ucwaningo olwenziwe yi-Zhengzhou Fruit Research Institute, i-Chinese Academy of Agricultural Sciences, luveze ukuthi i-quercetin, ihlangene nezinye izithelo ze-flavonoid, ingavimbela umsebenzi we-α-glucosidase nge-synergistically. I-α-Glucosidase idlala indima ebalulekile ku-hydrolysis yama-carbohydrate, futhi ukuvimbela umsebenzi wayo kungavimba ngempumelelo ukugaya nokumuncwa kwama-carbohydrate, ngaleyo ndlela kusize ukulawula amazinga kashukela wegazi we-postprandial. Ngokuncibilika kwayo okuhle kakhulu nokumunca, i-quercetin encibilika emanzini ingabamba iqhaza ngokuphumelelayo ekuvinjweni kwe-α-glucosidase, inikeze ukwesekwa okuqinile kokuthuthukiswa kwemikhiqizo esebenzayo okuhloswe ngayo ukulawula i-postprandial blood glucose. Lokhu kunomthelela omkhulu ekuphathweni kwezempilo kwansuku zonke kweziguli ezinesifo sikashukela noma lezo ezinezinga le-glucose eguquguqukayo.
2. Ukuvikelwa Kwempilo Yesibindi
I-quercetin encibilika emanzini iphinde ikhanye ekugcineni impilo yesibindi. Ucwaningo olwenziwa yithimba likaSolwazi u-Peng Cheng wase-Chengdu University of Traditional Chinese Medicine lubonise ukuthi i-quercetin ingenza ngcono isibindi esinamafutha ophuzo oludakayo ngokulamula ukudluliswa kwe-nuclear kwe-TFEB ukuze kunxeshezelwe ukunganele ngokwanele kwe-autophagy. Ukumuncwa okuthuthukisiwe kwe-quercetin encibilika emanzini kuyivumela ukuthi ifinyelele esibindini ngokushesha nangempumelelo, iqinise umsebenzi we-autophagic wamangqamuzana esibindi, ikhuthaze ukugaywa kwamafutha ngaphakathi kwesibindi, futhi kube lula ukuqedwa kwezinto eziyingozi. Lokhu kusiza ukuvimbela nokuthuthukisa izifo ezihlukahlukene zesibindi, njengesibindi esinamafutha kanye nesifo sesibindi esidakayo, ngokunciphisa umonakalo obangelwa utshwala nezinye izici esibindi.
3. Ukukhuthazwa Kokuvuselelwa Kwezinwele
Ukuqothuka kwezinwele kuwukukhathazeka okuvamile kubantu abaningi, futhi i-quercetin encibilika emanzini inikeza ikhambi elinoveli kule nkinga. Ucwaningo oluhlanganyelwe lwethimba likaSolwazi Qu Jing oluvela ku-Institute of Zoology, i-Chinese Academy of Sciences, lithole ukuthi i-quercetin ingakhuthaza ngempumelelo ukukhula kabusha kwezinwele ngokwenza kusebenze indlela ye-HIF-1 kumaseli e-endothelial we-follicle microenvironment yezinwele. I-quercetin encibilikayo emanzini ingangena kalula egazini futhi ifinyelele endaweni yezinwele, isebenzise ngokugcwele imiphumela yayo yokulawula ku-microenvironment ye-follicle yezinwele. Ikhuthaza ukuhlukaniswa nokwanda kwamaseli we-follicle stem cell, ngaleyo ndlela ikhuthaze ukukhula kwezinwele. Ukuthi ukulahlekelwa izinwele kubangelwa ingcindezi, ukungalingani kwama-hormone, noma ezinye izici, i-quercetin encibilika emanzini inesithembiso njengokwelashwa kwe-adjuvant ephephile nesebenzayo.
4. Ukuthuthukiswa Kwesistimu Yamasosha omzimba
I-Quercetin ngokwayo inemisebenzi ethile ye-immunomodulatory, njengokukhuthaza ukusebenza kwe-macrophage kanye nokugcinwa kwezici ezihlobene nokuzivikela komzimba. Ukufika kwe-quercetin encibilika emanzini kukhulisa lezi zinzuzo. Ukuncibilika kwawo okuhle kakhulu emanzini kuqinisekisa ukusatshalaliswa okufanayo emzimbeni, okuwenza ukwazi ukusebenza ngokunembe ezingxenyeni ezihlukahlukene zamasosha omzimba. Ithuthukisa umsebenzi wamangqamuzana omzimba omzimba futhi ikhuthaze ukugcinwa kwezici zokuzivikela komzimba njenge-tumor necrosis factor-α ne-interferon-γ, isiza umzimba ukuthi uvikeleke kangcono kuma-pathogen angaphandle futhi ikhulise kakhulu ukuzivikela okuphelele. Lokhu kunikeza abantu amandla okumelana okuqinile lapho bebhekene nezinsongo zezempilo ezifana namagciwane omkhuhlane kanye nezifo ezibangelwa amagciwane.

Iphrofayela Yokuphepha kanye Namathemba Esikhathi esizayo

Ukulungiswa kwe-quercetin encibilikayo emanzini kusebenzisa kakhulu izindlela zobuchwepheshe eziphephile nezivumelana nemvelo, njengobuchwepheshe be-nanomiclle okukhulunywe ngabo ekuqaleni. Lezi zindlela zithuthukisa ukuncibilika kwamanzi e-quercetin ngaphandle kokwethula amakhemikhali ayingozi, okuqinisekisa ukuphepha komkhiqizo. Ngaphezu kwalokho, ngenxa ye-bioavailability ethuthukisiwe, umthamo ophansi we-quercetin uyadingeka ukuze kuzuzwe izinzuzo ezifanayo zezempilo, kuqhubeke kuncishiswe ubungozi bokusabela okubi okungaba khona.
Ngokujula okuqhubekayo kocwaningo kanye nokusungulwa okusha okuqhubekayo kobuchwepheshe, i-quercetin encibilika emanzini isilungele ukukhombisa amandla amakhulu okusebenza ekudleni okusebenzayo, izithasiselo zokudla, izimonyo, kanye nemboni yezemithi. Emkhakheni wokudla okusebenzayo, kungafakwa eziphuzweni ezihlukahlukene kanye nokudla okulula, okuhlinzeka abathengi ngokuvikelwa kwezempilo okulula. Embonini yezimonyo, ukusebenzisa izakhiwo zayo zokuvuselela izinwele kanye ne-antioxidant, imikhiqizo enemisebenzi efana nokulahlekelwa izinwele kanye nokuguga kwesikhumba ingathuthukiswa. Emkhakheni wemithi, kunesithembiso esihle sokuqhubeka nokuhlola izicelo zayo ekwelapheni izifo ezingelapheki kanye nokusiza ekwelashweni kwezidakamizwa, kuvuleke ama-horizons amasha ocwaningo lwesikhathi esizayo lwezokwelapha nezempilo.

Izithenjwa

1.South Subtropical Crops Research Institute, Chinese Academy of Tropical Agricultural Sciences. (nd). Intuthuko Entsha ku-Nano Sustained-Release-Release Drug Carrier Materials. Kubuyiswe ku-http://m.toutiao.com/group/7164215338974839308/?upstream_biz=doubao
2.Peng, C., et al. (nd). I-Quercetin yehlisa i-ethanol - i-hepatic steatosis eyenziwe kumaseli e-L02 ngokwenza ukudluliselwa kwe-TFEB kusebenze ukuze kunxeshezelwe ukungasebenzi kahle kwe-autophagy. UCWANINGO LWE-PHYTOTHERAPY (Isigaba Sesibili ku-Chinese Academy of Sciences). Kubuyiswe kusizindalwazi sezemfundo
3.Qu, J., et al. (nd). I-Single-cell Profileing Yembula Indima Enamandla Ye-Quercetin Ekukhuthazeni Ukuvuselelwa Kwezinwele. Amaprotheni & Cell. Kubuyiswe ku-https://m.thepaper.cn/newsDetail_forward_21318679
4.Jin, Z., et al. (2024). I-Co-encapsulation ye-quercetin ne-resveratrol: Ukuqhathaniswa kwezingqimba ezihlukene ze-zein - carboxymethyl cellulose nanoparticles. Ijenali yamazwe ngamazwe ye-Biological Macromolecules, 263, i-Athikili 127439. https://doi.org/10.1016/j.ijbiomac.2024.127439
5.I-Zhengzhou Fruit Research Institute, i-Chinese Academy of Agricultural Sciences. (2024). Ama-Flavonoid Ezithelweni Alawula I-Postprandial Blood Glucose. Kubuyiswe kusukela ku-http://www.xinhuanet.com/science/20241105/c730eb7ee20a4e0ab8d2ec96570044ca/c.html

Okwedlule: I-Quercetin HPLC98% ejwayelekile yekhwalithi ye-USP40

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