Ohambweni lokuphishekela impilo kanye nokulibazisa, ucwaningo lwesayensi luhlala lusilethela amathemba amasha namathuba. Eminyakeni yamuva nje, i-NMN (nicotinamide mononleotide), into ebhekwa kakhulu ye-bioactive, ingene kancane kancane esweni lomphakathi futhi yaheha ukunakwa okubanzi. Yini ngempela? Futhi kungani iye yaqala ukubambelela ensimini yezempilo? Masinikeze izimfihlakalo ze-NMN ndawonye.
● Yini i-NMN?
I-NMN, okuyi-nicotinamide mononleotide, iyinhlekelele ekhona ngokwemvelo ekhona ngazo zonke izinhlobo zokuphila. Emzimbeni womuntu, i-NMN iyisisekelo esandulelayo sokuhlanganiswa kweCoenzyme I (NAD +). I-Coenzyme I (NAD +) ibamba iqhaza ekuphendukeni okuningi kwe-metabolic ngaphakathi kwamaseli futhi idlala indima ebalulekile ekugcineni imisebenzi evamile nobungqabavu bamaseli. Njengabantu ubudala, izinga leNad + emzimbeni womuntu liyancipha kancane kancane, okukholelwa ukuthi lihlobene kakhulu nezinguquko eziningi zomzimba ezihambisana nokuguga nokuvela kwezifo. Ukungezelela kwe-NMN kungakhuphula ngempumelelo okuqukethwe kweNad + emzimbeni, ngaleyo ndlela kunikeze ukusekelwa kwamandla okwanele kokusebenza okujwayelekile kwamaseli nokusiza ukugcina isimo sobusha.
● Umgomo osebenzayo we-NMN
Indlela yokwenza kwe-NMN ikakhulukazi ijikeleze ngokuphakama kwayo kwamazinga we-NAD +. Lapho singenisa i-NMN, idonswa ngokushesha ngumzimba futhi iguqulwe ibe yi-NAD + ngaphansi kwesenzo sochungechunge lwama-enzyme. Njenge-coenzyme yama-enzyme amaningi asemqoka, i-NAD + ibamba iqhaza ezinqubweni ezibalulekile zomzimba ngaphakathi kwamaseli, njenge-metabolism yamandla, ukulungiswa kwe-DNA, kanye nomthethonqubo we-gene nkulumo. Ngokuya nge-metabolism yamandla, i-NAD + ibandakanyeka kwinqubo yokuphefumula kwamaselula, ukusiza i-mitochondria ukuguqula izakhi zomzimba zibe yi-ATP, i-molecule yamandla amaseli angasebenzisa ngokuqondile. Amazinga anele we-NAD + anikela ekuthuthukiseni umsebenzi kanye nokusebenza kahle kweMitochondria, enikeza amandla amaningi amaseli futhi asenze sikwazi ukuba namandla amaningi namandla amaningi. Esicini sokulungiswa kwe-DNA, i-NAD + iyisisekelo esibalulekile se-PAPP (Poly ADP - Ribise Polymerase) Umndeni. Lapho amaseli elonakaliswa imisebe ye-ultraviolet, ukucindezelwa kwe-oxidative, njll. Ukugcina izinga eliphakeme le-NAD + kungathuthukisa umsebenzi wama-enzyme e-PARP, ukusheshisa inqubo yokulungisa ama-DNA, ukunciphisa ukunqwabelana kwezakhi zofuzo kanye nomonakalo weseli, nokusiza ukuvimbela ukuvela kokuguga - izifo ezihlobene. Ngaphezu kwalokho, iNad + nayo ibamba iqhaza ekuqondisweni komndeni wamaprotheni we-Sigtuins Protein. Amaprotheni ama-Sirtuins adlala izindima ezibalulekile ekugugeleni kwamaseli, ukulawulwa kwe-metabolic, izimpendulo zokuvuvukala, njll. Ngokwengeza i-NMN ukwandisa amazinga we-NAD +, kungasebenza ngokungaqondile amaprotheni ama-sigtuins futhi asebenzise imisebenzi efana nokubambezela ukuguga cell kanye nokwenza ngcono umsebenzi we-metabolic.
● Ukusebenza kwe-NMN
1: Kubambezele insendence
Inqubo yokuguga ihambisana nokwehla kancane kancane kwemisebenzi yezitho ezahlukahlukene nezinhlelo emzimbeni. I-NMN Ibambezela Inqubo Yokuguga emazingeni aphansi ngezindlela eziningi ezinjengezinga lokukhulisa amandla we-NAD +, ethuthukisa umsebenzi we-mitochondrial, ukuthuthukisa amaprotheni e-DNA. Ucwaningo lukhombisa ukuthi ukungezelwa kwe-NMN kungathuthukisa kakhulu imisebenzi yezilwane ezivivinyayo, njengokuthuthukisa amandla emisipha, ukwenza ngcono umsebenzi wokuziphilisa, nokwenza ngcono umsebenzi wokuqonda. Kubantu, ukungenisa isikhathi eside nge-NMN kulindeleke futhi ukuthi kubambezele ukuguga kwesikhumba, kunciphise ukubukeka kwemibimbi kanye neminyaka yobudala, ngcono izinga lokulala, ukuthuthukisa amandla emzimbeni jikelele, ukuvumela ukuthi silondoloze ubuhle nobuntu.
2: Khuphula Ukuvikeleka
I-NMN inomthelela omuhle wokulawula kumasosha omzimba. Ngakolunye uhlangothi, kungakhuthaza ukwanda nokwehlukanisa amaseli omzimba, kuthuthukise umsebenzi wamaseli omzimba, futhi uthuthukise amandla okuphendula ngomzimba. Ngakolunye uhlangothi, i-NMN isiza ukugcina umsebenzi ojwayelekile we-mitochondria ngamaseli omzimba, unikeze ukusekelwa kwamandla okwanele kwemisebenzi yamaseli omzimba. Ngokungezelela i-NMN, singakhulisa ukungavikeleki kwethu, ukunciphisa ubungozi bokugula, futhi kungcono ukubhekana nezinselelo zemvelo yangaphandle.
3:Thuthukisa umsebenzi we-metabolic
I-Metabolic Dysfunction iyimbangela yezifo eziningi ezingamahlalakhona, njengokukhuluphala, isifo sikashukela, izifo zenhliziyo, njalonjalo. I-NMN ingathuthukisa ukusebenza kwe-metabolic ngokulawula izindlela ze-metabolic ngaphakathi kwamaseli. Ucwaningo luthole ukuthi ukungezelwa kwe-NMN kungathuthukisa ukuzwela kwe-insulin, ukukhuthaza ukwamukelwa kanye nokusetshenziswa kwe-glucose, futhi kusize ukugcina ushukela wegazi. Ngasikhathi sinye, i-NMN ingakhulisa futhi i-metabolism enamafutha, yehlise ukunqwabelana kwamafutha emzimbeni, futhi idlale indima enhle ekuvikeleni nasekuthuthukiseni ukukhuluphala. Ngaphezu kwalokho, i-NMN inomphumela wokuvikela ohlelweni lwenhliziyo. Kunganciphisa amazinga we-lipid yegazi, ukuthuthukisa ukusebenza kwe-endothelial endothelial, futhi kunciphise ubungozi bezifo zenhliziyo. Kulabo abakhathazekile nge-Metabolic Health, i-NMN ngokungangabazeki iyisengezo sokudla okunempilo ngenani elingaba khona.
4:Thuthukisa umsebenzi wokuqonda
Ngokukhula kweminyaka yobudala, umsebenzi wobuchopho wehla kancane kancane, ukuwohloka kwememori, ukuwohloka kwememori, ukuphazamiseka kwengqondo nezinye izinkinga zikhathazeke kakhulu asebekhulile. I-NMN ikhombisile imiphumela ethembisayo ekwenzeni ngcono umsebenzi wokuqonda.
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Isikhathi sePosi: Mar-29-2025