Ohambweni lokuphishekela impilo nokubambezela ukuguga, ucwaningo lwesayensi luhlale lusilethela amathemba amasha kanye namathuba. Eminyakeni yamuva nje, i-NMN (Nicotinamide Mononucleotide), into ethathwa njenge-bioactive, kancane kancane iye yangena emehlweni omphakathi futhi yadonsa ukunaka okusabalele. Kuyini ngempela? Futhi kungani kuye kwaqala ukuhlanya okungaka emkhakheni wezempilo? Ake sihlole izimfihlakalo ze-NMN ndawonye.
●Iyini i-NMN?
I-NMN, okuyi-Nicotinamide Mononucleotide, i-molecule ekhona ngokwemvelo kuzo zonke izinhlobo zokuphila. Emzimbeni womuntu, i-NMN iyisandulela esiyinhloko sokwenziwa kwe-coenzyme I (NAD+). I-Coenzyme I (NAD+) ibamba iqhaza ekuphenduleni okuningi okubalulekile kwe-metabolic ngaphakathi kwamaseli futhi idlala indima ebalulekile ekugcineni imisebenzi evamile kanye nobungqabavu bamaseli. Njengoba abantu bekhula, izinga le-NAD+ emzimbeni womuntu liyehla kancane kancane, okukholakala ukuthi lihlobene eduze nezinguquko eziningi zomzimba ezihlobene nokuguga kanye nokuvela nokukhula kwezifo. Ukwengeza nge-NMN kungakhuphula ngempumelelo okuqukethwe kwe-NAD+ emzimbeni, ngaleyo ndlela kunikeze ukwesekwa kwamandla okwanele kokusebenza okujwayelekile kwamaseli futhi kusize ekugcineni isimo sobusha somzimba..
●Umgomo wokusebenza we-NMN
Indlela yokusebenza ye-NMN izungeza kakhulu ekuphakameni kwayo kwamazinga e-NAD+. Lapho singenisa i-NMN, imuncwa ngokushesha ngumzimba futhi iguqulelwe ku-NAD+ ngaphansi kwesenzo sochungechunge lwama-enzyme. Njenge-coenzyme yama-enzyme amaningi abalulekile, i-NAD+ ibamba iqhaza ezinqubweni ezibalulekile zomzimba ngaphakathi kwamaseli, njenge-energy metabolism, ukulungiswa kwe-DNA, kanye nokulawulwa kokuvezwa kwezakhi zofuzo. Ngokuya nge-metabolism yamandla, i-NAD+ ibandakanyeka enqubweni yokuphefumula kwamaselula, isiza i-mitochondria ukuguqula izakhi zibe i-ATP, i-molecule yamandla amangqamuzana angayisebenzisa ngokuqondile. Amazinga anele e-NAD+ anegalelo ekuthuthukiseni ukusebenza nokusebenza kahle kwe-mitochondria, enikeza amandla engeziwe kumaseli futhi asenze sikwazi ukuba namandla amaningi nobungqabavu. Esicini sokulungisa i-DNA, i-NAD+ iyingxenye ebalulekile yomndeni we-PARP (Poly ADP - Ribose Polymerase). Lapho amangqamuzana alinyazwa imisebe ye-ultraviolet, ukucindezeleka kwe-oxidative, njll., ama-enzyme e-PARP ayasebenza futhi asebenzisa i-NAD+ ukuze ahlanganise i-PAR (Poly ADP - Ribose), bese eqoqa amaprotheni ahlobene ukuze alungise i-DNA eyonakele. Ukugcina izinga eliphezulu le-NAD+ kungathuthukisa umsebenzi wama-enzyme e-PARP, kusheshise inqubo yokulungisa i-DNA, kunciphise ukunqwabelana kokuguqulwa kofuzo nokulimala kwamangqamuzana, futhi kusize ukuvimbela ukuvela kwezifo ezihlobene nokuguga. Ngaphezu kwalokho, i-NAD+ iphinde ibambe iqhaza ekulawulweni komndeni wamaprotheni we-Sirtuins. Amaprotheni e-Sirtuins adlala indima ebalulekile ekugugeni kwamangqamuzana, ukulawulwa kwe-metabolic, izimpendulo zokuvuvukala, njll. Njenge-coenzyme ye-Sirtuins, i-NAD + ingakwazi ukusebenzisa amaprotheni e-Sirtuins, ilawule ukubonakaliswa kwezakhi zofuzo, futhi ithinte imisebenzi yomzimba kanye nokuphila kwamaseli. Ngokwengeza i-NMN ukukhulisa amazinga e-NAD+, ingenza amaprotheni e-Sirtuins asebenze ngokungaqondile futhi yenze imisebenzi efana nokubambezela ukuguga kwamaseli kanye nokwenza ngcono ukusebenza kwe-metabolic.
●Ukusebenza Kwe-NMN
1: Ukubambezeleka kwe-senescence
Inqubo yokuguga ihambisana nokwehla kancane kancane kwemisebenzi yezitho nezinhlelo ezihlukahlukene emzimbeni. I-NMN ibambezela inqubo yokuguga ezingeni lamaselula ngokusebenzisa izindlela eziningi ezifana nokwandisa amazinga e-NAD+, ukuthuthukisa ukusebenza kwe-mitochondrial, ukuthuthukisa ikhono lokulungisa i-DNA, kanye nokwenza kusebenze amaprotheni e-Sirtuins. Ucwaningo lubonisa ukuthi ukugcwalisa nge-NMN kungathuthukisa kakhulu imisebenzi yomzimba yezilwane ezihlolwayo, njengokuthuthukisa amandla emisipha, ukuthuthukisa ukukhuthazela kokuzivocavoca, nokuthuthukisa ukusebenza kwengqondo, kuzenze zibonakale futhi ziziphathe esimweni esincane. Kubantu, ukuxhaswa kwesikhathi eside nge-NMN kulindeleke ukuthi kubambezele ukuguga kwesikhumba, kunciphise ukubukeka kwemibimbi namachashaza obudala, kuthuthukise ikhwalithi yokulala, futhi kuthuthukise izinga lempilo lonke lomzimba, okusivumela ukuba silondoloze ubuhle nobungqabavu .
2: Khulisa ukungatheleleki
I-NMN inomphumela omuhle wokulawula amasosha omzimba. Ngakolunye uhlangothi, kungakhuthaza ukwanda nokuhlukaniswa kwamaseli omzimba, kuthuthukise ukusebenza kwamangqamuzana omzimba, futhi kuthuthukise ikhono lokuphendula lomzimba lokuzivikela. Ngakolunye uhlangothi, i-NMN isiza ekugcineni umsebenzi ojwayelekile we-mitochondria kumaseli omzimba omzimba, inikeze ukwesekwa kwamandla okwanele kwemisebenzi yamaseli omzimba. Ngokungezelela nge-NMN, singakwazi ukuthuthukisa ukuzivikela kwethu, sinciphise ingozi yokugula, futhi sibhekane kangcono nezinselele zemvelo yangaphandle.
3:Thuthukisa umsebenzi we-metabolic
Ukungasebenzi kahle kwe-Metabolic kuyimbangela yezifo eziningi ezingapheli, njengokukhuluphala, isifo sikashukela, izifo zenhliziyo, njalonjalo. I-NMN ingathuthukisa ukusebenza kwe-metabolic ngokulawula izindlela ze-metabolic ngaphakathi kwamaseli. Ucwaningo luthole ukuthi ukwengeza nge-NMN kungathuthukisa ukuzwela kwe-insulin, kukhuthaze ukumuncwa kanye nokusetshenziswa kweglucose, futhi kusize ekugcineni ukuqina kukashukela egazini. Ngesikhathi esifanayo, i-NMN ingaphinde ikhulise umzimba we-fat metabolism, inciphise ukuqoqwa kwamafutha emzimbeni, futhi idlale indima enhle ekuvimbeleni nasekuthuthukiseni ukukhuluphala. Ngaphezu kwalokho, i-NMN inomphumela wokuvikela ohlelweni lwenhliziyo. Kunganciphisa amazinga e-lipid egazi, kuthuthukise ukusebenza kwe-vascular endothelial, futhi kunciphise ingozi yezifo zenhliziyo. Kulabo abakhathazeke ngempilo ye-metabolic, i-NMN ngokungangabazeki iyisengezo sokudla okunempilo esinevelu engaba khona.
4:Thuthukisa ukusebenza kwengqondo
Ngokukhula kweminyaka, ukusebenza kobuchopho kuncipha kancane kancane, ukuncipha kwenkumbulo, ukuphazamiseka kwengqondo nezinye izinkinga ziya ngokuya zikhathaza asebekhulile. I-NMN ibonise imiphumela ethembisayo ekuthuthukiseni ukusebenza kwengqondo.
Oxhumana naye:Judy Guo
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Isikhathi sokuthumela: Mar-29-2025