● Iyini i-urolixin A
I-Urolithin A (efushanisiwe njenge-UA) iyinhlanganisela yemvelo ye-polyphenol ekhiqizwa ama-microbiota amathumbu e-ellagitannins. Ama-Ellagitannins atholakala kakhulu ekudleni okunjengamahalananda, ama-strawberry, ama-raspberries, ama-walnuts, newayini elibomvu. Lapho abantu bedla lokhu kudla, ama-ellagitannins aguqulwa abe yi-urolithin A ngama-microbial populations athile emathunjini.
● Izici eziyisisekelo ze-urolithin A
Igama lesiNgisi: Urolithin A
Inombolo ye-CAS: 1143-70-0
Ifomu le-molecular. : C₁₃H₈O₄
Isisindo se-molecule: 228.2
Ukubukeka: Impushana eqinile ephuzi noma ekhanyayo ephuzi
● Ukusebenza kwe-Bioactivity nokusebenza kwe-urolixin A
1:Umphumela wokuguga
Thuthukisa umsebenzi we-mitochondrial: i-urolithin A ingashukumisa i-mitophagy, isize ukusula i-mitochondria eyonakele, ikhuthaze ukukhiqizwa kwe-mitochondria entsha, esebenzayo, ukuze kugcinwe amandla e-metabolism yamangqamuzana futhi kubambezele inqubo yokuguga.Ukwandisa isikhathi sokuphila kwamangqamuzana: Ngokuthuthukisa isimo sokusebenza kwamangqamuzana nokwandisa ubungqabavu beseli, i-urolixin A isiza ekwandiseni ukuphila kwamaseli.
2:Umphumela we-Neuroprotective
Yehlisa i-neuroinflammation: I-Urolitin A ingawela umgoqo wegazi-ubuchopho, inciphise i-amyloid beta (Aβ) kanye nezilonda ze-tau protein, futhi ibangele i-mitochondrial autophagy, ngaleyo ndlela ithuthukise izimpawu zezifo ze-neurodeergenerative ezifana nesifo se-Alzheimer kanye nesifo sika-Parkinson.Ukuthuthukiswa komsebenzi wenkumbulo: Ucwaningo luye lwabonisa ukuthi ukufunda i-urolixin, inkumbulo kumodeli ye-mitochondrial kungathuthukisa kakhulu.
3:Ukuvikelwa kwemisipha
Ukwandisa amandla emisipha nokukhuthazela: I-Urolixin A ingathuthukisa impilo yemisipha, ikhulise amandla emisipha nokukhuthazela, futhi inendima yokungenelela engase ibe khona ezifweni ezihlobene ne-muscular dystrophy.Ikhuthaza ukubuyiswa kwemisipha: Ngokulawula izindlela ezifana nokusebenza kwe-mitochondrial ngaphakathi kwamangqamuzana emisipha, i-urolixin A isiza asebekhulile noma abantu abanobunzima bokuhamba ngenxa yezifo ukuze benze umsebenzi odingekayo wokuvivinya umzimba futhi bakhuthaze ukubuyiswa kwemisipha.
4:Umphumela wokulwa nokuvuvukala
Ukuvinjelwa kwezinto ezivuthayo: i-urolithin A ingavimbela ukukhiqizwa nokukhululwa kwezinto ezivuthayo ezifana ne-IL-6 ne-TNF-α, futhi kunciphise impendulo yokuvuvukala.Ukulawulwa kwezindlela zokubonisa ukuvuvukala: Ngokuvimbela ukusebenza kwe-NF-κB, i-MAPK nezinye izindlela zokubonisa ukuvuvukala, i-urolitin A iphinde inciphise impendulo yokuvuvukala.
5:i-antioxidation
Ukukhipha ama-radicals mahhala: I-Urolixin A inekhono lokususa ngokuqondile ama-radicals mahhala futhi inciphise ukulimala kokucindezeleka okwenziwe nge-oxidative kumaseli.Ukuthuthukisa ukuzivikela kwe-antioxidant: I-Urolixin A ingathuthukisa ikhono lokuvikela elingapheli lamaseli ngokuvula indlela ye-Nrf2 antioxidant kanye nokulawula phezulu ukuvezwa kwama-enzyme ahlukahlukene e-antioxidant njenge-glutathione peroximudase kanye ne-super dissimudase.
6:Umphumela we-Antitumor
Ukuvimbela ukwanda kwamangqamuzana e-tumor: i-urolixin A ingavimbela ukwanda, ukuhlasela kanye nokumetastasis komdlavuza we-prostate, umdlavuza wekoloni kanye namanye amangqamuzana e-tumor.Ukufakwa kwe-tumor cell apoptosis: Ngokuvula izindlela zokubonisa ezihlobene ne-apoptosis, i-urolixin A ingabangela i-tumor cell apoptosis, ngaleyo ndlela ivimbele ukukhula kwesimila.
7:Thuthukisa izifo ze-metabolic
Ukulawulwa koshukela egazini kanye ne-lipid yegazi: i-urolithin A ingalawula indlela yokugaya umzimba futhi ibambe iqhaza elihle ekuthuthukiseni ushukela wegazi kanye namazinga e-lipid egazini.Ukulwa nokukhuluphala ngokweqile: Ngokufaka kusebenze amafutha ansundu namafutha amhlophe i-Browning, i-urolixin A ingasheshisa i-fat catabolism futhi ivimbele ukunqwabelana kwamafutha okubangelwa ukudla.
8:Thuthukisa isifo sezinso
Ukunciphisa ukulimala kwezinso: I-Urolixin A inganciphisa ukulimala kwezinso ngokuvula i-mitochondrial autophagy yamangqamuzana ezinso, ukunciphisa ukuqoqwa kwe-collagen, ukunciphisa ukwanda kwe-fibrocyte noma ukunciphisa ukufakwa kwezicubu ze-fiber ukuze kubambezele ukukhula kwenqubo ye-fibrosis.
● Ithemba lokusetshenziswa kwe-urolithin A
1:Ucwaningo nokuthuthukiswa kwezidakamizwa
I-Urolixin A iyinhloso ethandwayo yokuthuthukiswa kwezidakamizwa ezilwa nokuguga, i-neuroprotective, anti-tumor ngenxa yemisebenzi yayo ehlukahlukene yezinto eziphilayo.Okwamanje, Izikhungo eziningi zocwaningo kanye namabhizinisi seziqalile ukutadisha ukuthuthukiswa kwezidakamizwa ze-urolixin A, ngethemba lokuthuthukisa izidakamizwa ezisebenzayo neziphephile.
2:Ucwaningo nokuthuthukiswa kwezimonyo
Imiphumela ye-antioxidant ne-anti-inflammatory ye-urolixin A iyenza ibe namathemba okusebenza abanzi emkhakheni wezimonyo.Ngokwengeza i-urolixin A, izimonyo zingathuthukisa imiphumela yokuguga futhi zithuthukise isimo sesikhumba.
3:Ucwaningo nokuthuthukiswa kokudla
I-Urolixin A inenani elingase lisetshenziswe emkhakheni wokudla ngenxa yemisebenzi yayo ehlukahlukene yezinto eziphilayo.Ngokwengeza ukudla okunothe nge-ellagitannin noma izithako ze-urolithin A, ukudla kungathuthukisa izinzuzo zezempilo futhi kuhlangabezane nesidingo sabathengi sokudla okunempilo.
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Isikhathi sokuthumela: Mar-27-2025