Kwethulwa i-PQQ: umphini wokugcina wamandla wengqondo nomzimba

Kwethulwa i-PQQ: umphini wokugcina wamandla wengqondo nomzimba

I-Pyrlolquinoline Quinone, okubhekiselwa ku-PQQ, iyiqembu elisha le-prostetic elinemisebenzi efanayo yomzimba kumavithamini. Kutholakala kabanzi e-prokaryotes, izitshalo kanye nezilwane ezincelisayo, ezinjengama-soya avuthayo noma ama-natto, upelepele oluhlaza, izithelo ze-kiwi, i-papaya, isipinashi, isipinashi, ubisi lwebele, njll.

Eminyakeni yamuva nje, i-PQQ isiphenduke enye yezakhi zomzimba "zenkanyezi" ezidonsele ukunakwa okubanzi. Ngo-2022 no-2023, izwe lami lavuma i-PQQ ekhiqizwa yi-synthesis kanye nokuvutshelwa njengezinto ezintsha zokudla okuluhlaza.

Imisebenzi yemvelo ye-PQQ igxile kakhulu ezicini ezimbili. Okokuqala, kungasekela ukukhula kanye nentuthuko ye-mitochondria futhi kuvuse ukukhula okusheshayo kwamaseli abantu; Okwesibili, inezakhiwo ezinhle ze-antioxidant, ezingasiza ukususa ama-radicals wamahhala futhi anciphise ukulimala kweseli. Le misebenzi emibili yenza kube neqhaza elinamandla empilweni yobuchopho, impilo yenhliziyo, impilo ye-metabolic nezinye izici. Ngoba umzimba womuntu awukwazi ukuvumelanisa i-PQQ ngokwaso, kudinga ukufakwa ngezezithako zokudla.

Indima ka-01.pqq ekwenzeni ngcono ukuqonda ibaluleke kakhulu

NgoFebhuwari 2023, abacwaningi baseJapan banyathelisa iphepha lokucwaninga elinesihloko esithi "Pyrlolququinoline Quoonione i-Dirodium Usawoti Kuthuthukisa umsebenzi wobuchopho kubantu abasha nabadala" Kumagazini "Ukungenisa ulwazi lwe-PQQ kubantu abasha kubantu abadala eJapan. Imiphumela yocwaningo ethuthukisiwe.

Lolu cwaningo lwaluyisivivinyo esilawulwa yi-placebo esingavinjelwe kabili elihlanganisa amadoda angama-62 anempilo eJapan aneminyaka engu-20-65, enesilinganiso se-mini-Mental State Scale Scores ≥ 24, abagcina indlela yabo yokuphila yasekuqaleni ngesikhathi sokufunda. Isixuku sowesifazane. Izihloko zocwaningo zahlukaniswa ngokungahleliwe zibe yiqembu lokungenelela kanye neqembu elilawulwa nge-placebo, futhi zaziphathwa ngomlomo pqq (20 mg / d) noma ama-plusbo capsule nsuku zonke amasonto ayi-12. Uhlelo lokuhlola online oluthuthukiswe yinkampani esetshenziselwa ukukhonjwa ngamaviki 0/8/12. Uvivinyo lokuqonda luhlola imisebenzi elandelayo yobuchopho eyi-15.

Imiphumela ibonise lokho uma iqhathaniswa neqembu elilawulayo le-placebo, ngemuva kwamasonto ayi-12 okudla kwe-PQQ, inkumbulo eyinhlanganisela kanye nenqubomgomo yememori yomlomo yawo wonke amaqembu neqembu elidala lenyuka; Ngemuva kwamaviki ayi-8 yokudla kwe-PQQ, ukuguquguquka kweqembu le-Young Group, ukucubungula isivinini kanye nejubane lejubane lokubulawa kwandisiwe.

I-02 PQQ ayikwazi ukuthuthukisa kuphela umsebenzi wobuchopho asebekhulile, kepha futhi nokwenza ngcono ukuphendula kobuchopho kwabantu abasha!

Ngo-Mashi 2023, i-Journally Journal Food Food Food & umsebenzi ishicilele iphepha lokucwaninga elinesihloko esithi "I-Pyrlolloquinoline Quoonone Dionodium Usawoti Ithuthukisa Umsebenzi wobuchopho kubantu abadala abasebasha nabadala". Lolu cwaningo luphenye umthelela we-PQQ emsebenzini wokuqonda kwabantu abadala aneminyaka engu-20-65, wandise inani lesifundo se-PQQ se-PQQ avela kubantu asebekhulile kuya kubantu asebekhulile kuya kubantu abadala. Ucwaningo lufakazele ukuthi i-PQQ ingathuthukisa umsebenzi wokuqonda kwabantu bayo yonke iminyaka.

Ucwaningo luthole ukuthi i-PQQ, njengokudla okusebenzayo, ingathuthukisa umsebenzi wobuchopho kunoma yimuphi unyaka, futhi kulindeleke ukuthi yandise ukusetshenziswa kwe-PQQ njengokudla okusebenzayo okuvela kubantu asebekhulile kubantu abadala.

I-03 PQQ isebenza njengesishoshovu se- "cell energy factories" ukubuyisela impilo yabo

NgoMeyi 2023, i-cell Deach ishicilele iphepha lokucwaninga elinesihloko esithembisa ukukhuluphala ngokweqile i-Cardiolipipin-kuncike emcucopylic kanye nezokwelapha i-mitopharlial mitophalrial Amaphesenti wokudlulisa amaseli we-mesenchymal stem. Lolu cwaningo luthole i-PQQ ngokuhlola ukuthi ngabe umlingani we-intercellellel mitochondrial onikela ngezihloko ezikhuluphele (abantu abanenkinga ye-metabolic) kanye nokwelapha ama-mesenchymal stem cell (ama-MSCs) akhubazekile, nokuthi ukwelashwa okuhlosiwe kwe-mitochondrial) kungahlehlisa kanjani. Ukushintshashintsha kubuyisela impilo ye-mitochondrial ukunciphisa i-mitopharigy ekhubazekile.
Lolu cwaningo luhlinzeka ngokuqonda okuphelele kwamangqamuzana okulimaza ama-mitophagy kumaseli we-mesenchymal stem futhi kukhombisa ukuthi impilo ye-mitochondrial ingavuselelwa ngokulawulwa kwe-PQQ ukunciphisa i-mitophair mitophari.

I-04 PQQ ingathuthukisa umsebenzi we-metabolic

NgoMeyi 2023, i-athikili yokubuyekezwa enesihloko esithi "Pyrlolloquinoline-Quinone ukwehlisa ukunqwabelana kwamafutha kanye nokuthuthuka kokukhuluphala" kushicilelwe ephephabhukwini le-BOLCHI kanye nezifundo ezi-2 zeseli.
Imiphumela ikhombisa ukuthi i-PQQ inganciphisa amafutha omzimba, ikakhulukazi ukuqongelela amafutha okugcwala, ngaleyo ndlela kuvimbela ukukhuluphala kokudla. Ukusuka ekuhlaziyweni komgomo, i-PQQ ikakhulukazi kuvimbela i-lipogenesis futhi kunciphise ukunqwabelana kwamafutha ngokwenza ngcono umsebenzi we-mitochondrial futhi kuthuthukiswe imetabolism ye-lipid.

I-05 PQQ ingavimbela i-osteoporosisis ebangelwa ukuguga kwemvelo

NgoSepthemba 2023, iseli lokuguga lishicilele iphepha lokucwaninga elinesihloko esithi "I-Pyrlolququinoline Quinone inezela ukuphendula kwe-osteopororos ehlobene nemvelo nge-Axing McM3-Keap1-NRF1-Ukuhlukaniswa" online. Isifundo, ngokuhlola amagundane, sathola ukuthi izithako zokudla ze-PQQ zingavimbela i-osteoporosis ebangelwa ukuguga kwemvelo. Indlela eyisisekelo yamandla e-antioxidant anamandla e-PQQ ahlinzeka ngesisekelo sokuhlola sokusetshenziswa kwe-PQQ njengesengezo sokudla sokuvimbela amathambo ahlobene nobudala.
Lolu cwaningo luveza iqhaza elisebenzayo nendlela entsha ye-PQQ ekuvikeleni nasekwelapheni i-senile ama-osteoporosis, futhi kufakazela ukuthi i-PQQ ingahle isetshenziswe njengesengezo sokudla esiphephile nesisebenzayo sokudla. Ngasikhathi sinye, kwavezwa ukuthi i-PQQ isebenze isinali ye-MCM3-KRF1-NRF2 e-Osteoblasts, ilwela kabusha i-antioxidant yofuzo kanye ne-fbn1 genes, futhi ikhuthaza ukunqunyelwa kwamathambo e-osteoblast, futhi ithuthukisa ukuguga. indima ekwenzekeni kwe-osteoporosis yezocansi.

I-06 Supply PQQ ingavikela amaseli we-retinal ganglion futhi athuthukise impilo yamehlo!

NgoSeptemba 2023, iphephabhuku le-Acta Neuropathol lishicilele isifundo esivela ochwepheshe abafanele base-Ophthalmology baseStolinska, kanye nesibhedlela saseRoyal Victoria e-University of Pisa e-Italy. Ibizwa ngokuthi "i-pyrlocroquinoline quinone ishayela i-ATP synthesis eVitro naseVivo futhi ihlinzeka nge-retinal ganglion cell reeroprotection." Ucwaningo selufakazele ukuthi i-PQQ inomphumela wokuvikela amaseli we-retinal ganglion cell (RGC) futhi inamandla amakhulu njenge-ejenti entsha ye-neuroprotactive ekumelaneni ne-retinal ganglion apoptosis.
Ukutholwa kusekela indima engaba khona ye-PQQ njenge-ejenti yenoveli ebukwayo ye-neuroprotactive engathuthukisa ukuqina kwamaseli we-retinal ganglion ngenkathi kunciphisa ubungozi bemiphumela emibi engenzeka. Ngasikhathi sinye, abacwaningi bakholelwa ukuthi ukwengeza i-PQQ kuyindlela ephumelelayo yokugcina impilo yamehlo.

I-07 Supplement PQQ ingalawula i-Flora yamathumbu, ithuthukise umsebenzi we-thyroid, futhi inciphise ukulimala kwe-thyroid.

Ngo-December 2023, iqembu labacwaningi esibhedlela sabantu baseShanghai Senth esibhedlela seTongji University of Medicine bashicilela i-athircoun "Indima ye-PorBobioline yokubonisa ukuthi i-PQQ ibonisa ukuthi i-PQQ ingalawula i-flora yamathumbu, inqume Ukulimala kwamathumbu, futhi uthuthukise umsebenzi we-thyroid.
Ucwaningo luthole imiphumela yokungezwa kwe-PQQ ku-GD mice kanye ne-flora yaso yamathumbu:

Ngemuva kwe-01 ngemuva kokungezelelwa kwe-PQQ, iSerum Tshr kanye ne-T4 ye-GD Mice bancishisiwe, kanti usayizi wendlala yegilo wancishiswa kakhulu.

I-02 PQQ inciphisa ukuthuthuka kokuvuvukala kanye nokuxineka kwe-oxidative, futhi kunciphisa ukulimala okuncane kwamathumbu.

I-03 PQQ inomthelela obalulekile ekubuyiselweni kokuhlukahluka nokwakheka kwe-microbiotha.

I-04 uma iqhathaniswa neqembu le-GD, ukwelashwa kwe-PQQ kunganciphisa ubuningi be-lactobacilli eMice (lokhu kungaba yizokwelapha ezihlosiwe zenqubo ye-GD).

Ngokufingqa, ukungenisa i-PQQ kungalawula umsebenzi we-thyroid, kunciphise ukulimala kwe-thyroid, futhi kunciphise ukuvuvukala kanye nokucindezela okuncane, ngaleyo ndlela kudalule ukulimala kwamathumbu amancane amathumbu. Futhi i-PQQ nayo ingabuyisela ukwehlukahlukana kwamathumbu amathumbu.

Ngaphezu kwalezi zifundo ezingenhla kufakazela iqhaza elibalulekile kanye namathuba angenamkhawulo we-PQQ njengesengezo sokudla ukwenza ngcono impilo yabantu, izifundo ezedlule nazo ziye zaqhubeka nokuqinisekisa imisebenzi enamandla ye-PQQ.

I-08 PQQ ingathuthukisa umfutho wegazi ophakeme we-pulmonary

Ngo-Okthoba 2022, iphepha lokucwaninga elinesihloko esithi "I-Pyrlolquinoline Quinone (PQQ) lithuthukisa i-Pulmonry Hypertension ngokulawula i-Mitochondrial ne-Metabolic" yakhishwa kumagazini we-Pulmonary Pharmacology & Therapeutics, okuhlose ukuhlola iqhaza umfutho wegazi ophakeme we-pulmonary.
Imiphumela ikhombisa ukuthi i-PQQ ingadambisa ukungahambi kahle kwe-mitochondrial kanye nokulimala kwe-metabolic emaphepheni ama-artery ama-artery abushelelezi abushelelezi futhi kubambezele ukuthuthuka kwegazi kwegazi emagunjini; Ngakho-ke, i-PQQ ingasetshenziswa njenge-ejenti yokwelapha engaba khona yokwenza ngcono umfutho wegazi ophakeme we-pulmonary.

I-09 PQQ ingabambezela ukuguga kwamaseli futhi yandise impilo!

NgoJanuwari 2020, iphepha lokucwaninga linesihloko esithi I-Pyrlorquinoline Quinone Ukuvuza Ukuvuvukala kwe-TNF-α nge-P166 / P21 kanye neJagwed1 kanye neJagged1 Neagged1 Ukusayina Kwesikhangiso Kuthunyelwe Umphumela wokuguga we-PQQ emangqamuzaneni abantu. , imiphumela ikhombisa ukuthi i-PQQ Ibalekela Ukuguga Kwamaseli Omntu futhi inganweba isikhathi sokuphila.

Abaphenyi bathola ukuthi i-PQQ ingabambezela ukuguga kwabantu, futhi iqinisekise nalesi siphetho ngemiphumela yokubonisa ye-biomarkers eminingi efana ne-P21, P16, kanye ne-jagged1. Kuphakanyiswa ukuthi i-PQQ ingathuthukisa impilo yonke yabantu futhi banwebe isikhathi sokuphila.

I-10 PQQ ingavimbela ukuguga kokuguga futhi ilondoloze ukuzala

Ngo-Mashi 2022, iphepha lokucwaninga elinesihloko esithi "I-PQQ Dietrary Suppliction livimbela ukungasebenzi kahle kwama-agent-okubangelwa amagundane eMice" lishicilelwe ku-Prty Endocrinol, lihlose ukutadisha ukuthi ngabe i-Agentylating Agent Agent Agent Agent Agent dysfunction. umphumela.
Imiphumela ikhombisile ukuthi ukungenisa kwe-PQQ kwandise isisindo nosayizi wamaqanda, kubuyiselwe ingxenye yomjikelezo olimele, futhi kuvinjelwe ukulahleka kwama-follies kumagundane aphathwa ngama-alkylating agents. Ngaphezu kwalokho, ukungenisa okungeziwe kwe-PQQ kukhuphuke kakhulu isilinganiso sokukhulelwa nokukhuthazela usayizi wokulethwa ngokunye ukulethwa amagundane aphethwe kahle. Le miphumela igqamisa amandla okungenelela kokungezelelwa kwe-PQQ okungeziwe ku-Agentylating Agent-Elent-Elent Agent Dysfunction.

Ukugcina
Eqinisweni, njengesengezo esisha sokudla, i-PQQ iye yaqashelwa ngemiphumela yayo emihle ekudleni kanye nempilo. Ngenxa yemisebenzi yayo enamandla, ukuphepha okuphezulu nokuqina okuhle, kunamathemba abanzi wokuthuthuka emkhakheni wokudla okusebenzayo.
Eminyakeni yamuva nje, ukujula kolwazi, i-PQQ ithole isitifiketi esibanzi kakhulu futhi isetshenziswa kabanzi njengesengezo sokudla noma ukudla e-United States, eYurophu nakwamanye amazwe kanye nezifunda. Njengoba ukuqonda kwabathengi basekhaya kuyaqhubeka ukujula, kukholelwa ukuthi i-PQQ, njengesithako esisha sokudla, izokwakha umhlaba omusha emakethe yasekhaya.

Izinkomba:

1.Thengisakoshi m, Suzuki T, Nishihara E, et al. I-Pyrlocroquiconline Quoonione uSoltodium Usawoti uthuthukisa umsebenzi wobuchopho kuzo zombili abantu abadala abadala nabadala [J]. Ukudla Nokusebenza, 2023, 14 (5): 2496-501.Doi: 10.1039 / D2FO01515C.2. UMasanori Tamakoshi, uTomomi Suzuki, eiichiro nishihara, et al. I-Pyrlocroquiconline Quoonione uSwoti Usawoti uthuthukisa umsebenzi wobuchopho kuwo womabili abantu abadala nabadala. Ukudla okulawulwa ngokungahleliwe kokudla kwe-funct. 2023 Mar 6; 14 (5): 2496-2501. PMID: 36807425.3. Shakti Sagar, MD Imam Faizan, Nisha Chaudhary, et al. Ukukhuluphala okuphazamisa i-Cardiolipin-kuxhomekeke mitophagy kanye ne-therapellellellic ama-mitochondrial ukudluliswa kwamandla okudlulisa amaseli we-mesenchymal stem. I-Celle Read Dis dis. 2023 Meyi 13; 14 (5): 324. Doi: 10.1038 / S41419-023-05810-3. PMID: 37173333.4. Nur syafiqah mohamad Ishwak, Kazuto Ikemoto. I-pyrlolloquinoline-quinone ukwehlisa ukunqwabelana kwamafutha nokuthuthuka kokukhuluphala. FrontMolbiosci.2023MAY5: 10: 1200025. Doi: 10.3389 / FMOLB.2023.1200025. PMID: 37214340.5.Jie Li, Jing Zhang, Qi xue, et al. I-Pyrlolquinoline Quinone inezela i-osteoporosis egugile okuhlobene nemvelo nge-Voneral McM3-Keap1-NRF2-NRF2-NRF2-NRF2 Iseli lokuguga. 2023 Sep; 22 (9): E13912. DOI: 10.11111 / Acel.13912. EPUB 2023 Jun 26. PMID: 37365714.6. I-Alessio Canovai, James R Tribble, Melissa Jöe. et. al. I-Pyrlocroquiconline Quinone ishayela i-ATP synthesis eVitro naseVivo futhi inikeze i-Retinal Ganglion Cell Neuroprotection. I-Acta Neuropathol. 2023 Sep 8; 11 (1): 146. Doi: 10.11186 / S40478-023-01642-6. PMID: 37684640.7. UXiaoyan Liu, Wen Jiang, Ganghua Lu, et al. Indima engaba khona ye-pyrloquinoline quinone ukulawula umsebenzi we-thyroid kanye nokwakheka kwe-microbiosa yamathumbu wamathuna 'ezifweni zamathuna egunjini. Pol j microbiol. 2023 DECE 16; 72 (4): 443-460. DOI: 10.33073 / PJM-2023-042. Ukucophelela 2023 Dec 1. PMID: 38095308.8. Shafiq, Mohammad et al. I- "Pyrlolququinoline Quinone (PQQ) ithuthukisa umfutho wegazi ophakeme we-pulmonary ngokulawula imisebenzi ye-mitochondrial ne-metabolic." I-Pulmonary Pharmacology & Therapeutics Vol. 76 (2022): 102156. DII: 10.1016 / J.Punt.2022.1021569. Ying Gao, Teru Kamogashira, Chisato Fujimoto. et al. Ukubambezeleka kwama-Pyrlocroquinoline Quinone ukubambezeleka ukuvuvukala kwe-TNF-α nge-P16 / P21 kanye ne-Jag1 kanye neJagged1 News Clin exp Pharmacol Physiol. 2020 Jan; 47 (1): 102-110. DOI: 10.11111111111440-1681.13176. PMID: 31520547.10.dai, XIULIANG et al. "Ukungezelelwa kwe-PQQ Dietrary okungeziwe kuvimbela ukungasebenzi kahle kwama-agent agent ejele kumagundane." Umngcele e-endocrinology VOL. 13 781404. 7 Mari. 2022, Doi: 10.3389 / Fendo.2022.781404