Kwethulwa i-PQQ: I-Ultimate Energy Booster Yomqondo Nomzimba

Kwethulwa i-PQQ: I-Ultimate Energy Booster Yomqondo Nomzimba

I-Pyrroloquinoline quinone, ebizwa ngokuthi i-PQQ, iyiqembu elisha lokufakelwa elinemisebenzi efanayo yomzimba namavithamini. Itholakala kakhulu kuma-prokaryotes, izitshalo nezilwane ezincelisayo, ezifana nobhontshisi wesoya ovutshiwe noma i-natto, upelepele oluhlaza, izithelo ze-kiwi, i-Parsley, itiye, i-papaya, isipinashi, isilimo esidliwayo esinamagatsha anamanzi, ubisi lwebele, njll.

Eminyakeni yamuva nje, i-PQQ isibe ngesinye sezakhi "ezinenkanyezi" ezidonse ukunaka okusabalele. Ngo-2022 nango-2023, izwe lami lagunyaza i-PQQ ekhiqizwe ngokuhlanganisa nokuvutshelwa njengezinto ezintsha zokusetshenziswa kokudla.

Imisebenzi yebhayoloji ye-PQQ igxile kakhulu ezicini ezimbili. Okokuqala, ingasekela ukukhula nokuthuthukiswa kwe-mitochondria futhi ikhuthaze ukukhula okusheshayo kwamangqamuzana omuntu; okwesibili, inezici ezinhle ze-antioxidant, ezingasiza ekususeni ama-radicals mahhala futhi kunciphise ukulimala kwamangqamuzana. Le misebenzi emibili iyenza ibambe iqhaza elinamandla empilweni yobuchopho, impilo yenhliziyo nemithambo yegazi, impilo ye-metabolic nezinye izici. Ngoba umzimba womuntu awukwazi ukuhlanganisa i-PQQ uwedwa, idinga ukwengezwa ngezithako zokudla.

Indima ye-01.PQQ ekuthuthukiseni ukuqonda ibaluleke kakhulu

NgoFebhuwari 2023, abacwaningi baseJapan bashicilela iphepha lokucwaninga elinesihloko esithi "Pyrroloquinoline quinone disodium salt ithuthukisa ukusebenza kobuchopho kubo bobabili abadala abancane nabadala" kumagazini othi "Food & Function", bethula ulwazi lwe-PQQ kubantu abasha kanye nabantu abadala eJapan. Imiphumela yocwaningo oluthuthukisiwe.

Lolu cwaningo bekuwuhlolo olulawulwa ngokungahleliwe oluyimpumputhe ephindwe kabili ehlanganisa amadoda angama-62 aseJapane aneminyaka engu-20-65, anamaphuzu e-Mini-Mental State Scale ≥ 24, abagcine indlela yabo yokuphila yasekuqaleni phakathi nesikhathi socwaningo. Isixuku sabantu besifazane. Izifundo zocwaningo zihlukaniswe ngokungahleliwe zaba yiqembu lokungenelela kanye neqembu lokulawula i-placebo, futhi zaphathwa ngomlomo i-PQQ (20 mg / d) noma amaphilisi e-placebo nsuku zonke amaviki angu-12. Uhlelo lokuhlola ku-inthanethi olwakhiwe inkampani lwasetshenziselwa ukuhlonza emasontweni 0/8/12. Ukuhlolwa kwengqondo kuhlola imisebenzi yobuchopho engu-15 elandelayo.

Imiphumela yabonisa ukuthi uma kuqhathaniswa neqembu lokulawula i-placebo, ngemva kwamasonto angu-12 wokudla kwe-PQQ, inkumbulo eyinhlanganisela kanye nezibalo zenkumbulo zamazwi zawo wonke amaqembu kanye neqembu elikhulile lenyuka; ngemuva kwamaviki angu-8 wokuthatha i-PQQ, ukuguquguquka kwengqondo yeqembu elincane, isivinini sokucubungula kanye nesivinini sokwenza kukhuphuke.

02 I-PQQ ayikwazi nje ukuthuthukisa ukusebenza kobuchopho kwasebekhulile, kodwa futhi ithuthukise ukusabela kobuchopho babantu abasha!

NgoMashi 2023, iphephabhuku elaziwa umhlaba wonke i-Food & Function lashicilela iphepha lokucwaninga elinesihloko esithi "Pyrroloquinoline quinone disodium salt ithuthukisa ukusebenza kobuchopho kubantu abadala nabancane". Lolu cwaningo luphenye umthelela we-PQQ ekusebenzeni kwengqondo kwabantu abadala abaneminyaka engama-20-65, kwandise inani locwaningo lwe-PQQ kusukela kwabadala kuya kubantu abasha. Ucwaningo lufakazele ukuthi i-PQQ ingathuthukisa umsebenzi wokuqonda wabantu bayo yonke iminyaka.

Ucwaningo luthole ukuthi i-PQQ, njengokudla okusebenzayo, ingathuthukisa ukusebenza kobuchopho kunoma iyiphi iminyaka, futhi kulindeleke ukuthi yandise ukusetshenziswa kwe-PQQ njengokudla okusebenzayo kusuka kwabadala kuya kubantu bayo yonke iminyaka.

03 I-PQQ isebenza njengesiqalisi “sezimboni zamandla amaseli” ukuze zibuyisele impilo yazo

NgoMeyi 2023, i-Cell Death Dis yashicilela iphepha locwaningo elinesihloko esithi Ukukhuluphala ngokweqile kuphazamisa i-cardiolipin-dependent mitophagy kanye nekhono lokwelapha lokudlulisa i-intercellular mitochondrial lamaseli e-mesenchymal stem. Lolu cwaningo luthole i-PQQ ngokuhlola ukuthi amandla omnikeli we-intercellular mitochondrial wezifundo ezikhuluphele (abantu abanokuphazamiseka kwe-metabolic) kanye nomthelela wokwelapha wamangqamuzana e-mesenchymal stem (MSCs) akhubazekile, nokuthi ingabe ukwelapha okuqondiswe yi-mitochondrial kungakuhlehlisa yini. Ukuguquguquka kubuyisela impilo ye-mitochondrial ukuze kuncishiswe i-mitophagy ekhubazekile.
Lolu cwaningo lunikeza ukuqonda kokuqala okuphelele kwamangqamuzana kwe-mitophagy ekhubazekile kumaseli e-mesenchymal stem asuselwa ekukhuluphaleni futhi lubonisa ukuthi impilo ye-mitochondrial ingabuyiselwa ngomthetho we-PQQ ukuze kuncishiswe i-mitophagy ekhubazekile.

04 I-PQQ ingathuthukisa ukusebenza kwe-metabolic yomuntu

NgoMeyi 2023, indatshana yokubuyekezwa enesihloko esithi "Pyrroloquinoline-quinone yokunciphisa ukunqwabelana kwamafutha kanye nokuthuthukisa ukukhuluphala ngokweqile" yashicilelwa kujenali Front Mol Biosci, eyafingqa izifundo zezilwane ezi-5 kanye nezifundo zamaseli ezi-2.
Imiphumela ikhombisa ukuthi i-PQQ inganciphisa amafutha omzimba, ikakhulukazi ukunqwabelana kwamafutha e-visceral kanye nesibindi, ngaleyo ndlela kuvimbele ukukhuluphala kokudla. Kusukela ekuhlaziyweni komgomo, i-PQQ ivimbela ikakhulukazi i-lipogenesis futhi yehlise ukunqwabelana kwamafutha ngokuthuthukisa ukusebenza kwe-mitochondrial kanye nokukhuthaza i-lipid metabolism.

05 I-PQQ ingavimbela i-osteoporosis ebangelwa ukuguga kwemvelo

NgoSepthemba 2023, i-Aging Cell yashicilela iphepha locwaningo elinesihloko esithi "Pyrroloquinoline quinone yehlisa i-osteoporosis yemvelo ehlobene nokuguga ngenoveli ye-MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation" ku-inthanethi. Ucwaningo, ngokuhlolwa kwamagundane, lwathola ukuthi izithasiselo zokudla ze-PQQ zingavimbela i-osteoporosis ebangelwa ukuguga kwemvelo. Indlela eyisisekelo yomthamo onamandla we-antioxidant we-PQQ inikeza isisekelo sokuhlola sokusetshenziswa kwe-PQQ njengesithasiselo sokudla sokuvimbela ukukhumuzeka kwamathambo okuhlobene neminyaka.
Lolu cwaningo luveza indima ephumelelayo nendlela entsha ye-PQQ ekuvimbeleni nasekwelapheni i-senile osteoporosis, futhi kufakazela ukuthi i-PQQ ingasetshenziswa njengesithasiselo sokudla esiphephile nesisebenzayo ukuvimbela nokwelapha i-senile osteoporosis. Ngasikhathi sinye, kwavezwa ukuthi i-PQQ icupha isignali ye-MCM3-Keap1-Nrf2 kuma-osteoblasts, ibhala ngokubhaliwe ilawula ukubonakaliswa kwezakhi zofuzo ze-antioxidant kanye nezakhi zofuzo ze-Fbn1, ivimbela ukucindezeleka kwe-oxidative kanye ne-osteoclast bone resorption, futhi ikhuthaza ukwakheka kwamathambo e-osteoblast, ngaleyo ndlela kuvimbele ukuguga. indima ekuveleni kwe-osteoporosis yocansi.

06 Ukwengeza i-PQQ kungavikela amaseli e-retinal ganglion futhi kuthuthukise impilo yamehlo!

NgoSepthemba 2023, iphephabhuku i-Acta Neuropathol Commun lashicilela ucwaningo oluvela kochwepheshe bezifo zamehlo kanye nezazi ze-Eye Hospital yase-Karolinska Institutet e-Stockholm, eSweden, isikole sezokwelapha esidumile sase-Europe, kanye ne-Royal Victoria Eye and Ear Hospital e-Australia, kanye noMnyango Wesayensi Yezinto Eziphilayo wase-University of Pisa e-Italy. Inesihloko esithi "Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo futhi inikeza i-retinal ganglion cell neuroprotection." Ucwaningo luye lwafakazela ukuthi i-PQQ inomthelela ovikelayo kumaseli e-retinal ganglion (RGC) futhi inamandla amakhulu njenge-ejenti entsha ye-neuroprotective yokumelana ne-retinal ganglion cell apoptosis.
Okutholakele kusekela indima engaba khona ye-PQQ njenge-ejenti ye-neuroprotective yenoveli engathuthukisa ukuqina kwamaseli e-retinal ganglion ngenkathi inciphisa ubungozi bemiphumela emibi engaba khona. Ngasikhathi sinye, abacwaningi bakholelwa ukuthi ukufaka i-PQQ kuyindlela esebenzayo yokugcina impilo yamehlo.

07 Ukwengeza i-PQQ kungalawula ukumila kwamathumbu, kuthuthukise ukusebenza kwegilo, futhi kunciphise ukulimala kwegilo.

NgoZibandlela wezi-2023, ithimba labacwaningi abavela e-Shanghai Tenth People's Hospital yase-Tongji University School of Medicine lashicilela isihloko esithi "Indima Engaba Khona Ye-Pyrroloquinoline Quinone Yokulawula Ukusebenza Kwe-thyroid kanye Ne-Gut Microbiota Ukwakhiwa Kwezifo Zamathuna Emagundaneni" kumagazini i-Pol J Microbiol Kulesi sihloko, abacwaningi basebenzise imodeli ye-Pyrroloquinoline ukunciphisa ukulimala kwamathumbu, futhi kuthuthukise umsebenzi we-thyroid.
Ucwaningo luthole imiphumela ye-PQQ supplementation kumagundane e-GD kanye nezitshalo zawo zamathumbu:

I-01 Ngemva kokwengezwa kwe-PQQ, i-serum TSHR kanye ne-T4 yamagundane e-GD ancishisiwe, futhi ubukhulu begland yegilo bancishiswa kakhulu.

02 I-PQQ inciphisa ukuvuvukala kanye nengcindezi ye-oxidative, futhi inciphisa ukulimala okuncane kwe-epithelial yamathumbu.

03 I-PQQ inomthelela omkhulu ekubuyiseleni ukuhlukahluka nokwakheka kwe-microbiota.

04 Uma kuqhathaniswa neqembu le-GD, ukwelashwa kwe-PQQ kunganciphisa ukuchichima kwe-Lactobacilli kumagundane (lokhu ukwelashwa okungase kube okuqondiwe kwenqubo ye-GD).

Kafushane, ukwesekwa kwe-PQQ kungalawula ukusebenza kwegilo, kunciphise ukulimala kwegilo, futhi kunciphise ukuvuvukala nokucindezeleka okwenziwe nge-oxidative, ngaleyo ndlela kunciphise ukulimala kwe-epithelial encane yamathumbu. Futhi i-PQQ ingabuyisela futhi ukuhlukahluka kwezitshalo zamathumbu.

Ngaphezu kwalezi zifundo ezingenhla ezifakazela indima ebalulekile namandla angenamkhawulo we-PQQ njengesithasiselo sokudla sokuthuthukisa impilo yabantu, izifundo zangaphambilini nazo ziqhubekile nokuqinisekisa imisebenzi enamandla ye-PQQ.

08 I-PQQ ingathuthukisa umfutho wegazi ophakeme wamaphaphu

Ngo-Okthoba 2022, iphepha lokucwaninga elinesihloko esithi "Pyrroloquinoline quinone (PQQ) ithuthukisa umfutho wegazi ophakeme we-pulmonary ngokulawula imisebenzi ye-mitochondrial kanye ne-metabolic" yashicilelwa kumagazini i-Pulmonary Pharmacology & Therapeutics, okuhloswe ngayo ukuhlola indima ye-PQQ ekuthuthukiseni umfutho wegazi ophakeme wamaphaphu.
Imiphumela ikhombisa ukuthi i-PQQ ingadambisa ukungahambi kahle kwe-mitochondrial kanye nokungajwayelekile kwe-metabolic kumaseli emisipha abushelelezi we-pulmonary artery futhi ibambezele ukuqhubeka komfutho wegazi wamaphaphu kumagundane; ngakho-ke, i-PQQ ingasetshenziswa njenge-ejenti yokwelapha engaba khona ukuthuthukisa umfutho wegazi ophakeme wamaphaphu.

09 I-PQQ ingabambezela ukuguga kwamaseli futhi yandise impilo!

NgoJanuwari 2020, iphepha lokucwaninga elinesihloko esithi Pyrroloquinoline quinone libambezela ukuvuvukala okubangelwa yi-TNF-α ngokusebenzisa i-p16/p21 kanye ne-Jagged1 izindlela zokusayina ezishicilelwe ku-Clin Exp Pharmacol Physiol zaqinisekisa ngokuqondile umphumela wokulwa nokuguga we-PQQ kumaseli womuntu. , imiphumela ibonisa ukuthi i-PQQ ibambezela ukuguga kwamangqamuzana omuntu futhi ingase inwebe isikhathi sokuphila.

Abacwaningi bathole ukuthi i-PQQ ingabambezela ukuguga kwamangqamuzana omuntu, futhi yaqinisekisa lesi siphetho ngemiphumela yezinkulumo zama-biomarker amaningi afana ne-p21, p16, ne-Jagged1. Kuphakanyiswa ukuthi i-PQQ ingathuthukisa impilo yonke yabantu futhi yelule ubude bempilo.

I-10 PQQ ingavimbela ukuguga kwe-ovarian futhi igcine inzalo

NgoMashi 2022, iphepha lokucwaninga elinesihloko esithi "PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice" lashicilelwa ephephabhukwini i-Front Endocrinol, okuhloswe ngalo ukufunda ukuthi izithasiselo zokudla ze-PQQ zivikela yini ukungasebenzi kahle kwe-ovarian okubangelwa yi-alkylating. umphumela.
Imiphumela ikhombise ukuthi ukwesekwa kwe-PQQ kukhuphule isisindo nosayizi wama-ovari, kwabuyisela kancane umjikelezo we-estrous owonakele, futhi kwavimbela ukulahleka kwama-follicle kumagundane aphathwe ngama-alkylating agents. Ngaphezu kwalokho, ukwesekwa kwe-PQQ kwenyuse kakhulu izinga lokukhulelwa kanye nosayizi kadoti ngesikhathi sokubeletha ngakunye kumagundane alashwe yi-alkylating agent. Le miphumela igqamisa amandla okungenelela okufakwa kwe-PQQ ekungasebenzi kahle kwe-ovarian okubangelwa yi-alkylating agent.

Isiphetho
Eqinisweni, njengesengezo esisha sokudla, i-PQQ yaziwa ngemiphumela yayo emihle ekudleni nasempilweni. Ngenxa yemisebenzi yayo enamandla, ukuphepha okuphezulu nokuzinza okuhle, inamathemba okuthuthukiswa okubanzi emkhakheni wokudla okusebenzayo.
Eminyakeni yakamuva, ngokujula kolwazi, i-PQQ izuze isitifiketi esiphelele sokuphumelela futhi isetshenziswa kabanzi njengesengezo sokudla noma ukudla e-United States, Europe nakwamanye amazwe nezifunda. Njengoba ukuqwashisa kwabathengi basekhaya kuqhubeka nokujula, kukholakala ukuthi i-PQQ, njengesithako esisha sokudla, izodala umhlaba omusha emakethe yasekhaya.

Izithenjwa:

1.TAMAKOSHI M, SUZUKI T, NISHIHARA E, et al. I-Pyrroloquinoline quinone disodium usawoti ithuthukisa ukusebenza kobuchopho kubo bobabili abadala abancane nabadala [J]. Ukudla & Umsebenzi, 2023, 14(5): 2496-501.doi: 10.1039/d2fo01515c.2. Masanori Tamakoshi,Tomomi Suzuki,Eiichiro Nishihara,et al. I-Pyrroloquinoline quinone disodium usawoti ithuthukisa ukusebenza kobuchopho kubo bobabili abadala abancane nabadala. Umsebenzi Wokudla Olawulwa Ngokungahleliwe. 2023 Mar 6;14(5):2496-2501. PMID: 36807425.3. Shakti Sagar, Md Imam Faizan, Nisha Chaudhary, nabanye. Ukukhuluphala ngokweqile kukhubaza i-mitophagy encike ku-cardiolipin kanye nekhono lokwelapha le-intercellular mitochondrial lokudlulisa amaseli e-mesenchymal stem. I-Cell Death Dis. 2023 Meyi 13;14(5):324. doi: 10.1038/s41419-023-05810-3. PMID: 37173333.4. Nur Syafiqah Mohamad Ishak , Kazuto Ikemoto. I-Pyrroloquinoline-quinone yokunciphisa ukuqoqwa kwamafutha futhi ithuthukise ukuqhubeka kokukhuluphala. I-FrontMolBiosci.2023May5:10:1200025. doi: 10.3389/fmolb.2023.1200025. PMID: 37214340.5.Jie Li, Jing Zhang, Qi Xue, et al. I-Pyrroloquinoline quinone yehlisa i-osteoporosis yemvelo ehlobene nokuguga ngenoveli ye-MCM3-Keap1-Nrf2 impendulo ye-axis-mediated-mediated and Fbn1 upregulation. Iseli Eliguga. 2023 Sep;22(9):e13912. doi: 10.1111/acel.13912. Epub 2023 Jun 26. PMID: 37365714.6. U-Alessio Canovai, uJames R Tribble, uMelissa Jöe. et. al. I-Pyrroloquinoline quinone ishayela i-ATP synthesis in vitro kanye ne-vivo futhi inikeza i-retinal ganglion cell neuroprotection. I-Acta Neuropathol Commun. 2023 Sep 8;11(1):146. doi: 10.1186/s40478-023-01642-6. PMID: 37684640.7. Xiaoyan Liu , Wen Jiang , Ganghua Lu , et al. Indima Engaba Khona Ye-Pyrroloquinoline Quinone Yokulawula Umsebenzi We-thyroid kanye Ne-Gut Microbiota Ukwakhiwa Kwezifo Zama-Graves Emagundaneni. I-Pol J Microbiol. 2023 Dec 16;72(4):443-460. doi: 10.33073/pjm-2023-042. eCollection 2023 Dec 1. PMID: 38095308.8. Shafiq, Mohammad et al. "I-Pyrroloquinoline quinone (PQQ) ithuthukisa umfutho wegazi ophakeme wamaphaphu ngokulawula imisebenzi ye-mitochondrial kanye ne-metabolic." I-Pulmonary Pharmacology & Therapeutics vol. 76 (2022): 102156. doi:10.1016/j.pupt.2022.1021569. Ying Gao, Teru Kamogashira, Chisato Fujimoto. et al. I-Pyrroloquinoline quinone ibambezela ukuvuvukala okubangelwa i-TNF-α ngokusebenzisa i-p16/p21 kanye ne-Jagged1 izindlela zokusayina. I-Clin Exp Pharmacol Physiol. 2020 Jan;47(1):102-110. doi: 10.1111/1440-1681.13176. PMID: 31520547.10.Dai, Xiuliang et al. "I-PQQ Dietary Supplementation Ivimbela I-Alkylating Agent-Induced Ovarian Dysfunction kumagundane." Imingcele ku-endocrinology vol. 13 781404. 7 Mar. 2022, doi:10.3389/fendo.2022.781404